Ecological City of Bojnourd Based on Scenario-based Future Studies

The ecological city approach is one emerging of area, which has provided different perspectives on cities in terms of environmental and social dimensions.This approach is considered to provide a comprehensive and integrated way of achieving the sustainability goals with a focus on the environment, the economic development, and social justice.Such a

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Discrete Dynamic Model of the Mammalian Sperm Acrosome Reaction: The Influence of Acrosomal pH and Physiological Heterogeneity

The acrosome reaction (AR) is an exocytotic process essential for mammalian fertilization.It involves diverse physiological changes (biochemical, biophysical, and morphological) that culminate in the release of the acrosomal content to the extracellular medium as well as a reorganization of the plasma membrane (PM) that allows sperm to interact and

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Autophagy dictates sensitivity to PRMT5 inhibitor in breast cancer

Abstract Protein arginine methyltransferase 5 (PRMT5) catalyzes mono-methylation and symmetric di-methylation on arginine residues and has emerged Cam Pulley Assembly as a potential antitumor target with inhibitors being tested in clinical trials.However, it remains unknown how the efficacy of PRMT5 inhibitors is regulated.Here we report that autop

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